Lansoprazole is indicated in the treatment of conditions where a reduction of gastric acid secretion is required.
Indication: Duodenal ulcer, gastric ulcer, peptic ulcer associated with Helicobacter pylori, NSAID associated peptic ulcer, gastro-oesophageal reflux disease, acidrelated dyspepsia & Zollinger· Ellison syndrome .
Contraindication: Hypersensitivity to the ingredients of this drug .
Side Effect: headache, diarrhoea, rashes, pruritus, dizziness, urticaria, nausea & vomiting, constipation, flatulence & abdominal pain.
Precaution & warnings: Lansoprazole should be administered with care in the following patientsi. patients with a history of drug hypersensitivity,
ii. patients with hepatic dysfunction,
iii. in pregnant women or women having possibilities of being pregnant only if the expected therapeutic benefit is thought to outweigh any possible risk,
iv. it is advisable to avoid in nursing mothers,
v. the safety of lansoprazole in children has not been established.
Dosage & administration:
Benign gastric ulcer 30mg daily in the morning for 8 weeks. Duodenal ulcer-30mg daily in the morning for 4 weeks; maintenance 15 mg daily. NSAID associated duodenal or gastric ulcer 15 mg to 30mg once daily for 4 weeks, followed by a further 4 weeks if not healed completely.
Zollinger-Ellison syndrome (and other hypersecretory conditions)-initially 60mg once daily adjusted according to response; daily doses of 120mg or more is given in two divided doses.
Gastro-oesophageal reflux disease-30mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance therapy may be required, 15-30mg daily.
Acid-related dyspepsia-15mg to 30mg daily in the morning for 2-4 weeks.
Drug Interaction: In clinical studies lansoprazole does not show any significant interactions with warfarin, indomethacin, aspirin, ibuprofen, phenytoin, prednisolone, antacids, or diazepam in healthy subjects; but when administered concomitantly with theophylline, a minor increase (10%) in the clearance of theophylline was seen, which is unlikely to be of clinical importance.
Indication: Duodenal ulcer, gastric ulcer, peptic ulcer associated with Helicobacter pylori, NSAID associated peptic ulcer, gastro-oesophageal reflux disease, acidrelated dyspepsia & Zollinger· Ellison syndrome .
Contraindication: Hypersensitivity to the ingredients of this drug .
Side Effect: headache, diarrhoea, rashes, pruritus, dizziness, urticaria, nausea & vomiting, constipation, flatulence & abdominal pain.
Precaution & warnings: Lansoprazole should be administered with care in the following patientsi. patients with a history of drug hypersensitivity,
ii. patients with hepatic dysfunction,
iii. in pregnant women or women having possibilities of being pregnant only if the expected therapeutic benefit is thought to outweigh any possible risk,
iv. it is advisable to avoid in nursing mothers,
v. the safety of lansoprazole in children has not been established.
Dosage & administration:
Benign gastric ulcer 30mg daily in the morning for 8 weeks. Duodenal ulcer-30mg daily in the morning for 4 weeks; maintenance 15 mg daily. NSAID associated duodenal or gastric ulcer 15 mg to 30mg once daily for 4 weeks, followed by a further 4 weeks if not healed completely.
Zollinger-Ellison syndrome (and other hypersecretory conditions)-initially 60mg once daily adjusted according to response; daily doses of 120mg or more is given in two divided doses.
Gastro-oesophageal reflux disease-30mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance therapy may be required, 15-30mg daily.
Acid-related dyspepsia-15mg to 30mg daily in the morning for 2-4 weeks.
Drug Interaction: In clinical studies lansoprazole does not show any significant interactions with warfarin, indomethacin, aspirin, ibuprofen, phenytoin, prednisolone, antacids, or diazepam in healthy subjects; but when administered concomitantly with theophylline, a minor increase (10%) in the clearance of theophylline was seen, which is unlikely to be of clinical importance.