Mesalazine or 5-aminosalicylic acid. It available in 400 mg tablet.
Indication: Induction and maintenance of remission in ulcerative colitis.
Contraindication: Salicylate hypersensitivity; renal impairment (nephrotoxic).
Side Effect: Nausea, diarrhoea, and abdominal pain; headache; exacerbation of symptoms of colitis; rarely reversible pancreatitis, hepatitis, and interstitial nephritis; leucopenia, neutropenia, thrombocytopenia and aplastic anaemia reported; myocarditis, lupus phenomenon, fibrosing alveolitis also reported....
Caution: pregnancy and breast-feeding; blood disorders. Preparations that lower stool pH( e,g lactulose) may prevent release of mesalizine.
Dose: Acute attack, 6 tablets daily in divided doses; maintenance 3-6 tablets daily in divided doses.
Child: not recommended.
Child: not recommended.